Orf Virus: A New Class of Immunotherapy Drugs

Orf is one of the most widespread viral diseases worldwide, usually benign and self-limiting, and mainly affects not only sheep and goats, but also various other ruminants and mammals. The causative agent, orf virus (ORFV) is a member of the genus parapoxvirus, owing to its zoonotic importance and ability to cross-infect other species sporadically. ORFV encodes virulence and immunomodulatory factors that interfere with host inflammatory effect and antiviral immune mechanisms and induces a transient and complex cytokine response, initially represented by Th1-related cytokines followed by Th2-related cytokines. The ORFV has evolved several mechanisms to survive in the presence of the immune system, resulting in repeated infections. Currently, ORFV has been developed as vaccines in veterinary field. The unique host immune escape ability obtained by ORFV has made it one of the important candidates for prevention and treatment of various diseases (including chronic viral diseases, tumor, and liver fibrosis)

Simple Management of University Library in the New Period

This paper mainly illustrates the concept of simple management. Internet age, as a new period, has multi-facet and deep influence on university students. The development of internet technology has posed new challenges for university library management to renew the old management patterns, and brings to management staff new problems in studying “people oriented” management theory. The simple management of university library means creating a new situation where the focus is on humanized design and humanized service. It is the inevitable demand of the time, since only in this way can management in 21st century be better practiced.

Nova metoda mjerenja ekonomske konvergencije i njena primjena na centralne kineske provincije

In order to solve the shortcomings of classical convergence analysis and spatial econometric analysis, this paper proposes a delta statistics method to assess economic growth convergence of central China cities. The result shows to be more close to the reality by analyzing the drawbacks of the classical relative beta convergence, combining the advantages of gams convergence, reference panel data, co-integration theory with the time factor into model. Then, Monte Carlo simulation method is used to analyze its distribution, which shows that it obeys to the normal distribution assumption in large samples. At last, our method is applied to the analysis of economic convergence of central China.Kako bi se otklonili nedostaci klasične analize konvergencije i prostorne ekonometrijske analize, ovaj rad predlaže delta statističku metodu za potrebe procjene konvergencije ekonomskog rasta u gradovima centralne Kine. Rezultati pokazuju da se dolazi bliže stvarnosti analizirajući loše strane klasične relativne beta konvergencije kombinirajući prednosti gama konvergencije, referentnih panelnih podataka, kointegracijske teorije s vremenskim faktorom u modelu. Zatim, Monte Carlo model simulacije se koristi za analizu distribucije što pokazuje da odgovara pretpostavci normalne distribucije u velikim uzorcima. Naposljetku, naša se metoda primjenjuje na analizu ekonomske konvergencije u centralnoj Kini

Effects of food concentration and photoperiod on egg production, female life expectancy and population dynamics of the paracalanid copepod, Bestiolina amoyensis

The paracalanid copepod, Bestiolina amoyensis, is a widely distributed species occurring in subtropical inshore waters across the Pacific Ocean. Its small size, herbivorous feeding habit, and high adaptability make the species one of the most promising candidates as potential live feed for hatchery larval rearing. This study investigated effects of different feeding density of microalgae Isochrysis spp. (1 × 105, 2 × 105, 3 × 105, 4 × 105, and 5 × 105 cells ml–1) and photoperiod (8L:16D, 12L:12D, and 16L:8D) on productivity-related parameters, including egg production, female life expectancy and population dynamics of B. amoyensis. Results showed that total egg output over female lifespan, final population size and intrinsic rate of population of 12L:12D photoperiod treatments were always the highest among three photoperiod conditions, especially at the food concentration of 4 × 105 cells ml–1, indicating B. amoyensis had high reproductive performance and the population was in a more stable status. The number of nauplii from 4 × 105 cells ml–1 algal concentration treatment accounted for 75% of the population, and the ratio of females to males approaching 1:1 when photoperiod was 12L:12D; female life expectancy was 10.5 ± 0.6 days. In conclusion, our results showed that Isochrysis spp. is a suitable feed for B. amoyensis with an optimal concentration at 4 × 105 cells mL–1; the optimal photoperiod for B. amoyensis rearing is 12L:12D. The relatively long reproductive lifespan and high intrinsic population increase rate make B. amoyensis a good candidate to develop culture techniques for hatchery larval rearing

The Multireceiver Commitment Schemes

Existing commitment schemes were addressed under the classic two-party scenario. However, popularity of the secure multi-party computation in today\u27s lush network communication is motivating us to adopt more sophisticate commitment schemes. In this paper, we study for the first time multireceiver commitment in unconditionally secure setting, i.e., one committer promises a group of verifiers a common secret value (in computational setting it is trivial). We extend the Rivest model for this purpose and present a provably secure generic construction using multireceiver authentication codes (without secrecy) as a building block. Two concrete schemes are proposed as its immediate implementations, which are almost as efficient as an optimal MRA-code. Furthermore, to affirmatively answer the open question of Pinto, Souto, Matos and Antunes, we present also a generic construction (for two-party case) using only an A-code with secrecy. Finally, we show the possibility of constructing multireceiver commitment schemes using other primitives such as verifiable secret sharing. We leave open problems and believe the work will open doors for more interesting research

The effects of education and allocentrism on organizational commitment in Chinese companies: A multi-level analysis

As Chinese companies move to the world stage of business, they must leverage a more knowledgeable and collaborative workforce to meet new challenges. This study investigates how two prominent individual attributes, education and allocentrism, create work tension for human capital practices in Chinese companies. By surveying nearly 500 workers in four Chinese companies and using multi-level methodology, we demonstrate that higher levels of education work to the detriment of employees’ affective organizational commitment and positively influence seeking-to-leave behavior. In addition, this study suggests a positive relation between allocentrism and affective organizational commitment. Personalized leadership, a common leadership style in high-power distance cultures such as China, further exacerbates the problems with higher levels of education and diminishes the commitment benefits of allocentrism. Conversely, regardless of leadership style, if supervisors involve workers in decision-making activities, those workers who are more educated will become more committed to the organization and less likely to leave. Implications of these findings for practice and future research are discussed

A phenol-based compartmental ligand as a potential chemosensor for zinc(ii) cations

An "end-off"-type compartmental Lewis base, 2,6-bis(2-hydroxybenzyl-2-hydroxyethylamino)methyl-4-methylphenol (L), was synthesized as a potential chemosensor for Zn2+ ions. L coordinates two Zn2+ cations in methanol-water solution, forming a dinuclear complex whose formulation was confirmed by ESI-MS spectroscopy and Job's plot. The fluorescence of L is remarkably enhanced by Zn2+ as compared with K+, Ca2+, Mg2+, Cu2+, Pb2+, Mn2+, Fe3+, Fe2+, Co2+, Cd2+ and Ni2+ ions. The fluorescence enhancement is attributed to the complexation of Zn2+ with L, which interrupts the photoinduced electron transfer process and rigidifies the molecular skeleton of L. The fluorescence of L is greatly dependent on the acidity and polarity of the solvents. This compound may be used as a probe to sense Zn2+ ion in polar protic solvents after proper modification

A GIS-based approach for quantifying and mapping carbon sink and stock values of forest ecosystem: A case study

AbstractThis paper explored a GIS-based approach for quantifying and mapping economic values of carbon sink and stock of forest ecosystem. The approach highlighted use of GIS to develop database, perform spatial analysis and map economic values. And it was applied to a case of Tiantai County in Zhejiang Province of southeast China, for quantifying and mapping the values of vegetation carbon sink (VCSi), vegetation carbon stock (VCSt) and soil carbon stock (SCS) of forest ecosystem. By integrating forest inventory data and soil inventory data into GIS, vegetation photosynthesis method combined with forest biomass method and stem volume method were employed to quantify the VCSi and VCSt, and soil type method was applied to calculate the SCS. The selected carbon sink value and carbon stock values in the case area were mapped as data layers in GIS after gridding process, with each layer containing monetary values for every 25m cell. Results showed that the economic values of VCSi, VCSt and SCS of the case were approximately 895.26 million Yuan, 1369.40 million Yuan, 9303.21 million Yuan, respectively, and each value was spatially heterogeneous for the case. Depending on spatial maps of carbon sink and stock values, the suggestions and implications for improving carbon sink and stock are extensively discussed

Modeling on spatial block topological identification and the irprogressive failure analysis of slopeand cavernrock mass

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